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The mission of the Symposium of University Research and Creative Expression (SOURCE) is to provide a university-wide forum for Central Washington University (CWU) students, encouraging equity, diversity, and inclusivity, representing all disciplines and experience levels, to present their mentored research, scholarship, and creative works in a juried environment that meets professional conference standards and expectations.

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Monday, May 16 • TBA
Discovery of Novel Boronates; Structural Building Blocks of Potential Enzyme Inhibitors

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As bacteria and viruses continue to mutate and develop multidrug resistance, the urgency for developing more effective treatments increases. While this increase in mutation can be somewhat mitigated by the modification of current medicinal treatments, more long-term solutions involve the use of more novel remedies. Past investigations with the use of boron-containing compounds have shown significant potential as potent therapeutic compounds. Currently, there are five boron-containing FDA-approved medications. This supports the potential effectiveness of boron-containing chemical compounds and it indicates the need for more in-depth research, discovery, and development. Currently, the Fabry research group focuses its efforts on the synthesis of boron-modified inhibitors of HIV-1 aspartic protease. This work involves a homologation reaction followed by a nucleophilic bimolecular substitution. The obtained novel boronates are characterized using nuclear magnetic resonance (NMR) spectroscopy and gas chromatography/mass spectrometry (GC/MS). The ultimate goal of this project is to create a diverse library of novel boron compounds and to test the limits of synthetic boron chemistry.

Speakers
JO

Jacob Olson

Undergraduate, Biological Sciences;STEM Teaching

Mentors
LF

Levente Fabry-Asztalos

Mentor, Chemistry

Exhibitors

Monday May 16, 2022 TBA
Virtual

Attendees (4)