SOURCE 2022 has ended
The mission of the Symposium of University Research and Creative Expression (SOURCE) is to provide a university-wide forum for Central Washington University (CWU) students, encouraging equity, diversity, and inclusivity, representing all disciplines and experience levels, to present their mentored research, scholarship, and creative works in a juried environment that meets professional conference standards and expectations.

The 2022 SOURCE program is hybrid. Pre-recorded virtual talks are colored green and can be watched anytime. Live/in-person sessions with Zoom access can be found in the daily schedule. Thank you for joining us!

To vote for the 2023 SOURCE poster, click here
To learn more about SOURCE or give to support the students of Central visit, https://www.cwu.edu/source
Connect on social media with @CentralWashU, @cwusource, #SOURCE2022, #CWUTogether
Back To Schedule
Monday, May 16 • TBA
Discovery of Novel Boronates; Structural Building Blocks of Potential Enzyme Inhibitors

Sign up or log in to save this to your schedule, view media, leave feedback and see who's attending!

Feedback form is now closed.

As bacteria and viruses continue to mutate and develop multidrug resistance, the urgency for developing more effective treatments increases. While this increase in mutation can be somewhat mitigated by the modification of current medicinal treatments, more long-term solutions involve the use of more novel remedies. Past investigations with the use of boron-containing compounds have shown significant potential as potent therapeutic compounds. Currently, there are five boron-containing FDA-approved medications. This supports the potential effectiveness of boron-containing chemical compounds and it indicates the need for more in-depth research, discovery, and development. Currently, the Fabry research group focuses its efforts on the synthesis of boron-modified inhibitors of HIV-1 aspartic protease. This work involves a homologation reaction followed by a nucleophilic bimolecular substitution. The obtained novel boronates are characterized using nuclear magnetic resonance (NMR) spectroscopy and gas chromatography/mass spectrometry (GC/MS). The ultimate goal of this project is to create a diverse library of novel boron compounds and to test the limits of synthetic boron chemistry.


Jacob Olson

Undergraduate, Biological Sciences;STEM Teaching


Levente Fabry-Asztalos

Mentor, Chemistry


Monday May 16, 2022 TBA

Attendees (4)