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The mission of the Symposium of University Research and Creative Expression (SOURCE) is to provide a university-wide forum for Central Washington University (CWU) students, encouraging equity, diversity, and inclusivity, representing all disciplines and experience levels, to present their mentored research, scholarship, and creative works in a juried environment that meets professional conference standards and expectations.
The 2022 SOURCE program is hybrid. Pre-recorded virtual talks are colored green and can be watched anytime. Live/in-person sessions with Zoom access can be found in the daily schedule. Thank you for joining us!
To vote for the 2023 SOURCE poster, click here To learn more about SOURCE or give to support the students of Central visit, https://www.cwu.edu/source Connect on social media with @CentralWashU, @cwusource, #SOURCE2022, #CWUTogether
Organic compounds that contain sulfur (i.e., organosulfur compounds) are associated with rich flavors. Meanwhile, ~80% of small-molecule drugs contain a nitrogen atom and ~67% are found within a heterocycle. Specifically, N,S-heterocycles such as 4-thiazolidinones exhibit a diverse range of biological activities, including antifungal, antioxidant, cytotoxic, anti-inflammatory, anticonvulsant, anti-HIV, antitubercular, and many others. Organosulfur compounds are also present in several medicines, fragrances, and materials. A cost-effective and environmentally friendly method for the controlled synthesis of two types of organosulfur compounds; namely sulfoxides (one with two carbon-sulfur bonds and one sulfur-oxygen bond) and sulfones (one with two carbon-sulfur bonds and two sulfur-oxygen bonds) has been developed. The outcomes are achieved through controlled oxidation of cyclic compounds bearing a disulfide bridge (R-S-S-R) as well as a protein-type bond (referred to herein as disulfide-embedded lactams). The cost was controlled by using a cheap and commercially available catalyst known as N-fluorobenzenesulfonimide (NFSI). Water served as the solvent and the oxygen source for the controlled oxidation. Since water is a green and an environmentally friendly solvent, the successful execution of the proposed strategy has set the stage for the attainment of the highly coveted green chemistry status. A structure-activity relationship (SAR) study is being performed together with another group member and Dr. Dondji in the Department of Biological Sciences, with a focus on neglected tropical diseases, especially leishmaniasis.
